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mRNA COVID vaccines tied to drop in death rate for 4 years
A large national cohort study from France didn’t observe any increase in all-cause mortality in adults up to four years after receipt of a COVID mRNA vaccine, and vaccination was linked to a 74% lower risk of death from severe COVID-19 and a 25% lower risk of death from any cause.
The study, published last week in JAMA Network Open, is the first population-based study to look at differences in all-cause mortality between people who did and did not receive COVID vaccines 4 years after their first dose. It’s also the first study to examine long-term mortality among young people who are less likely to experience severe disease, according to the authors.
Researchers analyzed data from the French National Health Data System, identifying more than 28 million adults ages 18 to 59 who were alive on Nov 1, 2021. Of these, 22.7 million had received at least one mRNA dose from May to October 2021, while 5.9 million remained unvaccinated. The follow-up period extended through March 31, 2025, which provided a median of 45 months (almost four years) of observation.
After weighting for demographic factors and 41 underlying health conditions, the researchers found that vaccinated adults had a 74% lower risk of death from severe COVID and a 25% lower risk of all-cause mortality.
www.cidrap.umn.edu
A large national cohort study from France didn’t observe any increase in all-cause mortality in adults up to four years after receipt of a COVID mRNA vaccine, and vaccination was linked to a 74% lower risk of death from severe COVID-19 and a 25% lower risk of death from any cause.
The study, published last week in JAMA Network Open, is the first population-based study to look at differences in all-cause mortality between people who did and did not receive COVID vaccines 4 years after their first dose. It’s also the first study to examine long-term mortality among young people who are less likely to experience severe disease, according to the authors.
Researchers analyzed data from the French National Health Data System, identifying more than 28 million adults ages 18 to 59 who were alive on Nov 1, 2021. Of these, 22.7 million had received at least one mRNA dose from May to October 2021, while 5.9 million remained unvaccinated. The follow-up period extended through March 31, 2025, which provided a median of 45 months (almost four years) of observation.
After weighting for demographic factors and 41 underlying health conditions, the researchers found that vaccinated adults had a 74% lower risk of death from severe COVID and a 25% lower risk of all-cause mortality.
