Marijuana for pain?

The endocannabinoid system (ECS) is a biological system in the body that helps regulate and balance key bodily functions.

Research suggestsTrusted Source that the ECS may be a potential therapeutic target in numerous physiological conditions such as:

energy balance
appetite stimulation
blood pressure
pain
embryonic development
nausea and vomiting control
memory and learning
immune response

In addition, it may be a target for pathological conditions such as:

Parkinson’s disease
Huntington’s disease
Alzheimer’s disease
multiple sclerosis

Endogenous cannabinoids, or endocannabinoids, are naturally occurring, lipid-based neurotransmitters. Neurotransmitters are chemical messengers in the body that send signals between nerve cells.
https://www.medicalnewstoday.com/articles/endocannabinoid#definition
 
floridafan said:
Are sales strong for legal weed in Michigan? Here in Illinois its a massive industry with 40% of sales coming from out of state.
Click to expand...

I'm actually in Florida. And I'm not sure about sales, but I've never visited a dispensary where there's no wait.
 
Jarod said:
I havent smoked in 30 years, but From what I hear it's about $200 to get a card and it has to be renewed fairly often. Sure would be a LOT cheaper if it was legal to grow in your backyard.
Click to expand...

Agreed. So the card is 150, the appointment is $75. I have to renew annually. The good news...... I get the 150 back by just going to two different dispensaries. But it would definitely be easier if it was just completely legal. I suspect it won't be long.

I really don't smoke. I use a vape pen occasionally, and dab from time to time, but mostly for me, it's edibles. Gummies, chocolates, baked goods, tincture. Smoking is just too damn harsh for me. I know some people love it, it's just not my preference.
 
Concart said:
Agreed. So the card is 150, the appointment is $75. I have to renew annually. The good news...... I get the 150 back by just going to two different dispensaries. But it would definitely be easier if it was just completely legal. I suspect it won't be long.

I really don't smoke. I use a vape pen occasionally, and dab from time to time, but mostly for me, it's edibles. Gummies, chocolates, baked goods, tincture. Smoking is just too damn harsh for me. I know some people love it, it's just not my preference.
Click to expand...

In my day there was just smoke. I do not understand what all that other stuff is. Too complicated for me.
 
Jarod said:
In my day there was just smoke. I do not understand what all that other stuff is. Too complicated for me.
Click to expand...

im not much on edibles. th buzz is too long and slow onset but there is no flame from lighters going into your lungs

There are vape cartridges that has THC as well as CBD. what I try to use
 
Trumpet said:
Maybe if you were to get high once in a while, you won't be such a jerk.
Click to expand...

Absolutely on the button.

I know fewer people who would benefit from giving up pot...than I do people who would benefit from using it occasionally.

In fact, I know many, many more people who would benefit from using it...than I do people who would benefit from giving it up.

(Lots of them right here in the MAGA segment.)
 
anatta said:
im not much on edibles. th buzz is too long and slow onset but there is no flame from lighters going into your lungs

There are vape cartridges that has THC as well as CBD. what I try to use
Click to expand...

I always figured CBD was snake oil, does it really do anything?
 
Jarod said:
In my day there was just smoke. I do not understand what all that other stuff is. Too complicated for me.
Click to expand...

Edibles are a completely different high. Smoother and longer lasting. Also take longer to kick in. Totally different than smoking flower.
 
Jarod said:
I always figured CBD was snake oil, does it really do anything?
Click to expand...
look at my post on endocnnibinoid system ( endo means in the body).. It's vastly hyped and not a miracle compound but it has it's place

cbd-systems.jpg


Dopamine D2 Receptor Binding: Many antipsychotic pharmaceutical drugs target the D2 receptor, and this probably explains CBD’s benefits in anecdotally helping to manage schizophrenia.
TRPV1 Activation: TRPV1 receptors are Involved in regulating body temperature, pain, and inflammation. Other molecules known to affect TRPV1 channels include anandamide, capsaicin, AM404, and a myriad of other cannabinoids such as CBG, CBN, CBDV, CBC, and THCV.
PPAR-gamma Activation: The nuclei of our body’s cells contain PPAR-gamma receptors, and these assist in the removal beta-amyloid plaque (major contributor to Alzheimer’s), in addition to lipid uptake, dopamine release, and insulin sensitivity. This activity explains why CBD may benefit those with schizophrenia, Alzheimer’s, and diabetes.
5-ht1A Activation (at higher doses): 5-ht1a receptors assist in moderating addiction, sleep, anxiety, pain perception, appetite, nausea, and vomiting.
Adenosine Enhancement: CBD moderately prevents adenosine reuptake (like caffeine), through inhibition of the equilibrate nucleoside transporter 1 (ENT1). This likely explains the reported benefits of CBD for inflammation and autoimmune conditions.
Glycine Receptor Potentiation: Glycine receptors are the most ubiquitous inhibitory receptor in the CNS, and they play a major role in pain proprioception via the spinal cord/brainstem. CBD potentiates these receptors, which most likely reduces inflammation and chronic pain.
GPR55 Antagonization: GPR55 receptors exist in abundance in the brain (mostly the cerebellum) and aid in controlling blood pressure and bone density. Also, GPR55 receptors encourage the proliferation of cancer cells when turned on (CBD helps turn them off). These findings shed light on CBD’s possible role in helping patients with high blood pressure and osteoporosis.
 
anatta said:
Marijuana receptors are all over the body (Endocannibinoid system) = the various cannibinoids act more to regulate the bodys responses to pain (inflammation ) and others

Weed doesnt block pain and is nowhere effective on moderate to severe pain. Opoids do

The CDC has issued less restrictive guidelines for opiates since many legit pain patients were cut off after their draconian rules

Both have their places but weed is not a pain blocker
Click to expand...

there is a big difference between CBD and THC and how the body reacts and deals with it.

https://www.miamiherald.com/news/nation-world/national/article262356207.html

A government-backed review of cannabis research found that THC could be more effective for soothing chronic pain than CBD. The review, published in the journal Annals of Internal Medicine and funded by the U.S. Department of Health and Human Services, found that although cannabinoids can be generally helpful for chronic pain, products with a higher THC-to-CBD ratio may be more potent than products with a higher CBD-to-THC ratio.

Read more at: https://www.miamiherald.com/news/nation-world/national/article262356207.html#storylink=cpy
 
You must log in or register to reply here.
Back
Top