Senator could be a goal for him. The previous governor and now 70 year old Senator Rick Scott may choose to retire after a second term in 2030. DeSantis is governor until JAN27. If he chose to run again and won, he could serve half his term then go for the Senate. Rubio has been Senator since 2011 and may choose to leave in 2028. I'm certain the inner circle of the Republican Party has quietly discussed the numbers.
He can't run again. Term limits.