The South African strain of Covid-19 has a lower response to the vaccines. Hopefully, it is not enough to make the vaccines ineffective, but because we have no idea how effective they are in preventing transmission, we can not be sure.
The UK strain is not causing a problem with the vaccines, but is twice as transmissible as the original Covid-19.
At some point the two are probably going to intermix. If two different strains of a virus infect the same cell, at the same time, the viruses that come from that will share traits of both strains.
So lots of bad news. This is quickly moving towards being seasonal, which might mean we will be dealing with this for decades.
As with any problem, giving up hope does nothing. But, false hope also does nothing good. We have to keep working hard to defeat this.