It is all about rolling the dice. I plant a wide variety because you never know which will be victor and which will be the vanquished. Saw my first squash beetle and carpet bombed with sevin last week. Other than deer, those are my biggest garden nemesis. I find that having a healthy crop of sunflowers diverts japanese beetles away from the things I want to eat as they really really love them sunflowers to feast on and the sunflowers generally survive rather unscathed.
I do a lot of smaller plots instead on one giant garden which helps as well. If one bed falls victim to something, there is usually more of it elsewhere. I did have to build a tomato pen to keep the deer off them. I tried all the other scent stuff but nothing worked great, so have a 10 foot by 30 foot tomato kennel now

I have tomatoes just in cages other places but double rowed that thing, and am running peas, cucumbers, and Christmas beans along the fence and underplanted the tomatoes with beets and chard, so it is working thus far and serves many purposes.
I am also having a potato contest. I planted several in 5 gal. buckets and then planted a 4X8 raised bed of them super dense so I am going to see once and for all which method is better. I am rooting for the buckets because I loathe digging potatoes in July and can just dump them out when the time comes. Potatoes grown in the south just don't keep that well so I don't go overboard with them.
My corn and okra are a complete bust this year. Not sure why. too much rain maybe. I only have a handful of each coming up when I planted beaucoup more than that, but all the hot peppers seem to be smashing it again this year.