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Thread: Does AstraZeneca’s COVID vaccine give longer-lasting protection than mRNA shots?

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    Default Does AstraZeneca’s COVID vaccine give longer-lasting protection than mRNA shots?

    .
    I'm so glad that I've received two Astra inoculations. The role of killer T-cells is downplayed in favour of antibodies but long term are more effective.

    Last week, AstraZeneca’s chief executive officer said the company’s COVID vaccine may provide longer-lasting protection than mRNA vaccines like Pfizer’s, especially in older people.

    CEO Pascal Soriot said this might explain the United Kingdom’s more stable hospitalisation rate compared to the escalating COVID situation in continental Europe.

    The UK used the AstraZeneca vaccine a lot more widely than other European countries, many of which restricted its use to older age groups or abandoned using it altogether after reports of very rare blood clots.

    The theory behind this is the AstraZeneca vaccine may provide more durable “T cell protection”. T cells are a crucial part of our immune system, and differ from antibodies.

    There’s not enough evidence yet to support the CEO’s claim. But we do know a lot more about adenovirus vector vaccines, such as AstraZeneca’s, as they’ve been around for decades, while mRNA vaccines are relatively newer.

    Theoretically, it is possible adenovirus vector vaccines do give more durable protection against COVID via T cells.

    Let me explain.

    What is AstraZeneca’s vaccine again?

    AstraZeneca’s COVID vaccine is an adenovirus vector vaccine.

    This means it uses an adenovirus – a common type of virus that affects humans and many other animals. The adenovirus is genetically modified so it doesn’t replicate.

    It’s used as a way to deliver the vaccine’s information into our cells.

    In this case, the information packaged in the adenovirus tells our body how to make the coronavirus spike protein. This teaches our immune system how to deal with the coronavirus if we’re exposed.

    Adenovirus vectors have been used in medicine for a few decades in other vaccines and also cancer therapy. They’re very good at stimulating both antibody production and T cell responses.

    What are T cells?

    Antibodies bind tightly to a specific target, locking onto invading viruses and preventing them from entering our cells.

    But the immune system is more than just antibodies.

    T cells are also really important for our immune response, and have different roles. One type, known as “killer T cells”, attack and destroy virus-infected cells.

    Another type, known as “helper T cells”, interpret the nature of the infection and help the immune system respond appropriately. This includes activating killer T cells to destroy virus-infected cells, and also helping B cells make antibodies
    Antibodies wane over time, which can lead to more breakthrough infections in fully vaccinated people.

    When viruses are not stopped by antibodies, we rely on killer T cells to eradicate the virus. And T cells almost certainly help prevent severe outcomes if you get COVID.

    It’s a lot harder for a virus to escape a T cell-based immune response. So a vaccine that generates strong T cell immunity should help retain effectiveness over time against variants including Delta and Omicron.

    https://theconversation.com/does-ast...a-shots-172609

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    Default

    I think that is English, so no.

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    Primavera;
    01-24-2020
    Sorry to spoil your fun but this isn't the pandemic the Left has been hoping for, nasty evil sods that they are.

    https://www.justplainpolitics.com/sh...ht=Coronavirus
    Get lost, maggot. You're a zombie.
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    We don't know what happened after that . "

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    Default

    Quote Originally Posted by Jack View Post
    I think that is English, so no.
    Well you've proved consistently that thinking is not for you. AZN is an Anglo-Swedish company with an impeccable ethical track record, unlike crooks like Pfizer. Have you ever heard of killer T-cells I'm thinking not!
    Last edited by cancel2 2022; 11-29-2021 at 11:25 AM.

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    Default

    Quote Originally Posted by Primavera View Post
    .
    I'm so glad that I've received two Astra inoculations. The role of killer T-cells is downplayed in favour of antibodies but long term are more effective.

    Last week, AstraZeneca’s chief executive officer said the company’s COVID vaccine may provide longer-lasting protection than mRNA vaccines like Pfizer’s, especially in older people.

    CEO Pascal Soriot said this might explain the United Kingdom’s more stable hospitalisation rate compared to the escalating COVID situation in continental Europe.

    The UK used the AstraZeneca vaccine a lot more widely than other European countries, many of which restricted its use to older age groups or abandoned using it altogether after reports of very rare blood clots.

    The theory behind this is the AstraZeneca vaccine may provide more durable “T cell protection”. T cells are a crucial part of our immune system, and differ from antibodies.

    There’s not enough evidence yet to support the CEO’s claim. But we do know a lot more about adenovirus vector vaccines, such as AstraZeneca’s, as they’ve been around for decades, while mRNA vaccines are relatively newer.

    Theoretically, it is possible adenovirus vector vaccines do give more durable protection against COVID via T cells.

    Let me explain.

    What is AstraZeneca’s vaccine again?

    AstraZeneca’s COVID vaccine is an adenovirus vector vaccine.

    This means it uses an adenovirus – a common type of virus that affects humans and many other animals. The adenovirus is genetically modified so it doesn’t replicate.

    It’s used as a way to deliver the vaccine’s information into our cells.

    In this case, the information packaged in the adenovirus tells our body how to make the coronavirus spike protein. This teaches our immune system how to deal with the coronavirus if we’re exposed.

    Adenovirus vectors have been used in medicine for a few decades in other vaccines and also cancer therapy. They’re very good at stimulating both antibody production and T cell responses.

    What are T cells?

    Antibodies bind tightly to a specific target, locking onto invading viruses and preventing them from entering our cells.

    But the immune system is more than just antibodies.

    T cells are also really important for our immune response, and have different roles. One type, known as “killer T cells”, attack and destroy virus-infected cells.

    Another type, known as “helper T cells”, interpret the nature of the infection and help the immune system respond appropriately. This includes activating killer T cells to destroy virus-infected cells, and also helping B cells make antibodies
    Antibodies wane over time, which can lead to more breakthrough infections in fully vaccinated people.

    When viruses are not stopped by antibodies, we rely on killer T cells to eradicate the virus. And T cells almost certainly help prevent severe outcomes if you get COVID.

    It’s a lot harder for a virus to escape a T cell-based immune response. So a vaccine that generates strong T cell immunity should help retain effectiveness over time against variants including Delta and Omicron.

    https://theconversation.com/does-ast...a-shots-172609
    The AZD1222 vaccine against COVID-19 has an efficacy of 63.09% against symptomatic SARS-CoV-2 infection.

    Longer dose intervals within the 8 to 12 weeks range are associated with greater vaccine efficacy.
    This vaccine is about effective as J&J vaccine?!!

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    Woman blames AstraZeneca ‘booster jab’ for her hair falling out
    PHUKET: A second Phuket person has blamed COVID vaccination for severe hair loss, this time a 41-year-old saleswoman at a motorcycle dealership in Phuket Town.

    https://www.thephuketnews.com/woman-...-out-82176.php
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    Quote Originally Posted by signalmankenneth View Post
    The AZD1222 vaccine against COVID-19 has an efficacy of 63.09% against symptomatic SARS-CoV-2 infection.

    Longer dose intervals within the 8 to 12 weeks range are associated with greater vaccine efficacy.
    This vaccine is about effective as J&J vaccine?!!
    Run out of cartoons Kenny? Another that's never heard of killer T-cells, you shouldn't believe everything you read in Readers Digest.

    AstraZeneca said Monday that the Covid-19 vaccine it developed with the University of Oxford reduced both mild and serious forms of the disease, paving the way for a likely U.S. authorization of the vaccine.

    Doctors, regulators, and government officials the world over are likely to breathe a sigh of relief at the results, which are better than expected and appear materially higher than those in previous studies.

    The two-dose vaccine reduced symptomatic disease by 79%, the company said in a press release, and reduced severe Covid-19 and hospitalisation by 100%. AstraZeneca said that the vaccine was equally effective in people over 65, where it had 80% efficacy.
    Last edited by cancel2 2022; 11-29-2021 at 11:31 AM.

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    I love when SK and Guno take turns hard fucking Primavera.





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    From your link -
    All COVID vaccines stimulate our bodies to produce both antibodies and T cells.

    So the key questions are: does AstraZeneca’s vaccine produce a longer-lasting T cell response than the mRNA vaccines? And might this be one reason why the UK, which relied heavily on the AstraZeneca vaccine, has a more stable hospitalisation rate than other parts of Europe?

    Unfortunately, there are not enough data yet to answer these conclusively.
    So the answer to the question is, "there is no evidence to support such a claim." In fact with the lack of data it is possible that the reverse is true in that AstraZeneca’s COVID vaccine provides less protection.
    "We are all born ignorant, but one must work hard to remain stupid."

    "Any fool can criticize, condemn and complain - and most fools do."

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