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Thread: Johns Hopkins University Scientists Suggest Reclassification of Psilocybin Mushrooms

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    Default Johns Hopkins University Scientists Suggest Reclassification of Psilocybin Mushrooms

    Researchers from Johns Hopkins University have recommended that psilocybin, the active compound in hallucinogenic mushrooms, be reclassified for medical use, potentially paving the way for the psychedelic drug to one day treat depression, PTSD, and anxiety and help people stop smoking.

    The suggestion to reclassify psilocybin from a Schedule I drug, with no known medical benefit, to a Schedule IV drug, which is akin to prescription sleeping pills, was part of a review to assess the safety and abuse of medically administered psilocybin.

    Before the Food and Drug Administration can be petitioned to reclassify the drug, though, it has to clear extensive study and trials, which can take more than five years, the researchers wrote.

    The analysis was published in the October print issue of Neuropharmacology, a medical journal focused on neuroscience.

    The study comes as many Americans shift their attitudes toward the use of some illegal drugs. The widespread legalization of marijuana has helped demystify drug use, with many people now recognizing the medicinal benefits for those with anxiety, arthritis and other physical ailments.

    Psychedelics, like LSD and psilocybin, are illegal and not approved for medical or recreational use. But in recent years scientists and consumers have begun rethinking their use to combat depression and anxiety.

    “We are seeing a demographic shift, particularly among women,” said Matthew Johnson, an associate professor of psychiatry and behavioral sciences at Johns Hopkins and one of the study’s authors. Among the research he has conducted, he said, “we’ve had more females in our studies.”

    Microdosing, or the use of psychedelics in small, managed doses, has become a popular way to try to increase productivity and creative thinking, particularly among the technorati in Silicon Valley. It’s even a plot point in the CBS show “The Good Fight.”

    For decades, though, researchers have shunned the study of psychedelics. “In the 1960s, they were on the cutting edge of neuroscience research and understanding how the brain worked,” Dr. Johnson said. “But then it got out of the lab.”

    Research stopped, in part, because the use of mind-altering drugs like LSD and mushrooms became a hallmark of hippie counterculture.

    The researchers who conducted the new study included Roland R. Griffiths, a professor in the departments of psychiatry and neurosciences at the Johns Hopkins University School of Medicine, who is one of the most prominent researchers on the behavioral and subjective effects of mood-altering drugs. The researchers reviewed data going back to the 1940s.

    Dr. Johnson said that the F.D.A. had approved a number of trials of psilocybin. If its use is approved for patients, he said, “I see this as a new era in medicine.”

    He added, “The data suggests that psychedelics are powerful behavioral agents.” In legal studies, he said, participants are given a capsule with synthetic psilocybin. (They are not given mushrooms to eat, which is how the drug is most often ingested.)

    He warned, though, that psilocybin is not a panacea for everyone. In their analysis, the researchers called for strict controls on its use. There are areas of risk, too, for patients with psychotic disorders and anyone who takes high doses of the drug.
    https://www.nytimes.com/2018/10/03/s...cheduleiv.html

    Looks like the alternative medicine wave isn't stopping at marijuana. The age of benzos, painkillers, and SSRIs is coming to a close, it seems.

    What's more interesting about the changing winds on psychedelics drugs is many clinical trials are suggesting they could be a miracle treatment for addiction. Something to consider in the midst of an opioid crisis getting worse by the day.
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    schedule IV ???

    Maybe a II

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    Quote Originally Posted by TrippyHippy View Post
    https://www.nytimes.com/2018/10/03/s...cheduleiv.html

    Looks like the alternative medicine wave isn't stopping at marijuana. The age of benzos, painkillers, and SSRIs is coming to a close, it seems.

    Edit: What's more interesting about these clinical trials on psychedelics opening back up is many are suggesting they could be a miracle treatment for addiction. Something to consider in the age of an opioid crisis getting worse by the day.
    They've been successfully experimenting with Ecstasy for ptsd, too.
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    Quote Originally Posted by TrippyHippy View Post
    https://www.nytimes.com/2018/10/03/s...cheduleiv.html

    Looks like the alternative medicine wave isn't stopping at marijuana. The age of benzos, painkillers, and SSRIs is coming to a close, it seems.

    What's more interesting about the changing winds on psychedelics drugs is many clinical trials are suggesting they could be a miracle treatment for addiction. Something to consider in the midst of an opioid crisis getting worse by the day.
    Ours is an utterly ignorant and idiotic society with regard to this type of thing, and many others come to think of it. We believe, but do not think.

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    Quote Originally Posted by Bigdog View Post
    They've been successfully experimenting with Ecstasy for ptsd, too.
    Bart O'Kavanaugh's wife and daughters could benefit from it, it should be fast tracked.

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    Quote Originally Posted by anatta View Post
    schedule IV ???

    Maybe a II
    Nah. Schedule II drugs are defined as drugs with a high potential for addiction, abuse. Psilocybin mushrooms have not been found to have any physically addictive qualities. Quite the opposite, in fact, clinical trials have found they are "anti-addictive" drugs that can reduce dependence on other substances.
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    Quote Originally Posted by TrippyHippy View Post
    Nah. Schedule II drugs are defined as drugs with a high potential for addiction, abuse. Psilocybin mushrooms have not been found to have any physically addictive qualities. Quite the opposite, in fact, as many trials are suggesting they are "anti-addictive" drugs that can reduce dependence on other substances.
    psychotropic drugs are deceptively addictive.
    I think I dropped acid like 1000 days in a row in high school for the altered state. severe psychological dependence.

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    Quote Originally Posted by anatta View Post
    psychotropic drugs are deceptively addictive.
    I think I dropped acid like 1000 days in a row in high school for the altered state. severe psychological dependence.
    Umm you are either baldfaced lying for the purpose of making your point, or you were not taking LSD. LSD acts as a 5-HT autoreceptor agonist on 5-HT1A receptors in the LC, the RN, and the cortex. It inhibits firing and serotonin release of these cells. It also acts as a partial agonist on the postsynaptic 5-HT1A site. When 5-HT1A and 5-HT1A get agonized or are binded to by LSD they downregulate (which severely spikes tolerance). It is impossible to retain the psychotropic effects from dropping LSD even just twice in a row unless you double the dose the second time. So to keep the effects of LSD doing it 1000 days in a row you'd have been taking thousands of tabs of acid by the end. I seriously doubt you were able to get your hands on that amount much less pay for it.
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    Quote Originally Posted by TrippyHippy View Post
    Umm you are either baldfaced lying for the purpose of making your point, or you were not taking LSD. LSD acts as a 5-HT autoreceptor agonist on 5-HT1A receptors in the LC, the RN, and the cortex. It inhibits firing and serotonin release of these cells. It also acts as a partial agonist on the postsynaptic 5-HT1A site. When 5-HT1A and 5-HT1A get agonized or are binded to by LSD they downregulate (which severely spikes tolerance). It is impossible to retain the psychotropic effects from dropping LSD even just twice in a row unless you double the dose the second time. So to keep the effects of LSD doing it 1000 days in a row you'd have been taking thousands of tabs of acid by the end. I seriously doubt you were able to get your hands on that amount much less pay for it.
    any drug that hits neuroreceptors builds tolerance.

    I was dealing. I had yellow sunshine and some window pain ,and I think purple haze and blue microdot.
    white lightning and blotter of course
    I had more acid then I could sell in high school and just dropped it for the fuck of it.
    I'm counting in night tripping as well

    same with mushrooms in the early 80's. I'd put out a bowl for parties, or pack a lunch for work
    and toss in a few caps/stems. *munch munch*
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    Quote Originally Posted by anatta View Post
    any drug that hits neuroreceptors builds tolerance.
    Yes, and psilocybin/LSD specifically build tolerance far quicker than your average run of the mill drug because of their unique effect on your serotonin compared with other drugs. Again, unless you were doubling the dose each time, you're lying or were getting bunk sheets. And if you were doubling the dose every day for 1000 days you were being incomprehensibly stupid and I'm surprised you're even still around to talk about it, that has nothing to do with the chemical qualities of the drug and more to do with you having issues. Not being combative here, just being real with you.
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    The U.S. has drug problems.
    I suspect some of those problems are a consequence of our success as a nation.

    In the 18th century life was tough. Most persons would during the course of their lives be food generators, farmers, ranchers, etc.
    Indoor plumbing, and central heat were unknown. Life was hard, and lives were short.

    Our lives are much easier now. We don't have to shovel out the horse stall. We don't have to saddle the horse every time we want to go to the store for a quart of homogenized milk.

    And some of us seem to find their abundance of leisure time suited to recreational drug experimentation.

    That's probably a bad idea.

    BUT !!

    The Drug War is an even worse idea.
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    Quote Originally Posted by anatta View Post
    ...

    Animal and human studies indicate low abuse and no physical dependence potential.

    Major national surveys indicate low rates of abuse, treatment-seeking and harm.

    Mushrooms with variable psilocybin content are used illicitly, with a few lifetime use occasions being normative among users.
    Studies with psilocybin and LSD contributed to the development of abuse potential assessment methods, in part because it was quickly recognized that they differed in several key respects from opioids, sedatives, and stimulants which were then emerging as prototypic substances of abuse. In contrast to these drugs, any abuse potential-related effects associated with LSD, psilocybin, and related substances appeared to be unreliable and limited to specific conditions such as time of assessment, dose, and individual, social and experiential factors. In further contrast, the predominant and most reliable effects seemed to be effects thought to limit use and abuse (e.g., fear, anxiety, dysphoria, and physical discomfort including gastrointestinal upset). Thus, a leading addiction scientist and director of the ARC, Dr. William Martin, stated the following in a 1973 review of preclinical studies of psychedelic drugs: “The abuse of LSD-like hallucinogens came as somewhat of a surprise to many of the early experimenters with these drugs” (Martin, 1973, p. 149). Nonetheless, while he did acknowledge that certain doses of LSD could produce pleasure in some volunteers (Belleville et al., 1956), Martin's (1973) review indicated that most of the preclinical and clinical findings of the 1950s and 1960s were not indicative of a prototypic drug of abuse.
    https://www.sciencedirect.com/scienc...296?via%3Dihub
    Last edited by TrippyHippy; 10-09-2018 at 03:02 PM.
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    Quote Originally Posted by anatta View Post
    any drug that hits neuroreceptors builds tolerance.

    I was dealing. I had yellow sunshine and some window pain ,and I think purple haze and blue microdot.
    white lightning and blotter of course
    I had more acid then I could sell in high school and just dropped it for the fuck of it.
    I'm counting in night tripping as well

    same with mushrooms in the early 80's. I'd put out a bowl for parties, or pack a lunch for work
    and toss in a few caps/stems. *munch munch*
    Being a drug dealer is not the same as being a neuroscientist, and your anecdotes are not double blinded studies.

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    Quote Originally Posted by TrippyHippy View Post
    Yes, and psilocybin/LSD specifically build tolerance far quicker than your average run of the mill drug because of their unique effect on your serotonin compared with other drugs. Again, unless you were doubling the dose each time, you're lying or were getting bunk sheets. And if you were doubling the dose every day for 1000 days you were being incomprehensibly stupid and I'm surprised you're even still around to talk about it, that has nothing to do with the chemical qualities of the drug and more to do with you having issues. Not being combative here, just being real with you.
    of course I wasdn't doubling doses.
    I don'tknow where you get the idea you have to double doses,anymore then you have to double doses on narcotics.
    A tolerance doesn't mean you double doses -it means you build up a tolerance and have to increase doses

    and to the rest of your posts no one is claiming physical addiction on psychotropics, but they are habit forming
    to the point severe psychological dependency is a risk..

    For awhile it was just for the fuck of it. Trip and do this, and trip and do that.
    Then it became needed to not feel like a worn out dishrag - not getting high, just feeling normal

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    Quote Originally Posted by Fentoine Lum View Post
    Being a drug dealer is not the same as being a neuroscientist, and your anecdotes are not double blinded studies.
    oh please. double blind studies are not needed with placebos and treatment personnel not knowing who gets what.

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